The best hit and runners may be the ones that remove themselves from play because of 1 card
November (?): Storm Emeralda featuring Mega Rayquaza ex
You Find the Villains Lair Like the variants of Draw Two, each set carries with it a Cancel variant with some slight upside
A lot of cheap white removal cards are temporary, only taking cards out of play until the removal itself is removed, like Seam Rip, which can also only target nonland permanents that cost two mana or less
If they do, they can give a creature in their graveyard and encore cost equal to its mana cost, meaning several temporary copies of that card can potentially be put into play for a high-impact turn
Your group might decide that players lose at 15 poison counters instead of 10, remove Commander Damage altogether, allow the use of silver-bordered cards, permit a technically illegal Commander for a flavorful deck, or even establish its own rules around proxies and mulligans