digimon 1st edition booster box Universe: Appli Monsters Grab your other Digimon cards and get ready to play Digimon Special Limited Set Booster

Legendary Six Samurai - Enishi would also take care of problem cards by returning them to the hand as a Quick Effect.

Creature - Avatar Whip of Erebos Creatures you control have lifelink

Overall, there are plenty of ways to disrupt the opponent's hand, and some of them are more permanent, but Iono is the most efficient way of doing so

Allies has the same issue, but possibly only for one year until Zendikar Rising

This can really rack up over multiple turns, especially if you have more than one down

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