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They lose threat and time

In cube life totals are more generally relevant (as in most matchups do make two life a cost, even if small) while in constructed there are far more matchups where it simply doesn't matter at all

While life gain has traditionally been viewed as a weak mechanic, it's improved over time with the addition of extra payoffs and is a force to be reckoned with in limited formats like sealed and draft

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Mishra fled to the deserts of Dominaria, while Urza moved to Yotia, a coastal region of Dominaria

You can target your own cheap items or characters as a way to draw cards