For Yshtola, it came down to a mix of popularity of the character as well as being a spellcaster, her story and character development offered a wide range of abilities and moments to pull from to lead the deck
Outside of removal, there's other powerful spells like the game-ender Exsanguinate, and the value engine Lingering Souls, both of which work well with Y'shtola's abilities due to being greater than mana value 3 when cast
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That slots into fun builds with something like Dr
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From the losing players view, a lost match versus early game Neo Exdeath can only lead to a negative experience as he/she has lost not to his own mistakes, but only by being unlucky and for him/her, the game was basically decided right at the beginning, therefore being a waste of time