Against Despia, neither card is particularly effective, which makes things quite tough, but if you have Called by the Grave, you can counter Branded in Red, which opens up a path to victory
Learning the ropes is made easier by the games structure decks, each of which focuses on a general concept - whether its fairly straightforward dragons or the more advanced Pendulum mechanics, which alter cards effects based on their position on the battlefield
It does not hurt by any means to use a couple powerful spells in a Monster Mash just like the variants of history did with Reborn and Heavy, but it does hurt if you are running a lot of monster-dependent cards like Witch of the Black Rose or Gallis the Star Beast
Dragonmaid Tidying can be used to revive milled Laundrys to get more mills on later turns
Pendulum Pendulum Summoning involves setting two "pendulum scales" using pendulum monsters, a type of monster that can act as a continuous spell in the Pendulum Zone or as a regular monster
Once per turn: You can send 1 "The Agent" monster from your Deck to the Graveyard, and if you do, this card's Level becomes the Level of the monster sent to the Graveyard by this effect