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CC-647 is a Cereblon modulator
S)-AHPC-acetamido-O-PEG4-C2-Br Synonyms CAS Number n/a Related CAS Molecular Formula C34H51BrN4O9S Molecular Weight 771
09 SMILES Cl
HaloTag PEG4 Azide Ligand CAS Number Related CAS Molecular Formula C14H28ClN3O4 Molecular Weight 337
The strain in DBCO’s cyclooctyne ring drives the reaction forward by releasing energy when it transitions to the triazole product
DBCO-Dap(m-PEG4)-Val-Cit-PAB(m-PEG8) Size:100mg CC-647 is a Cereblon modulatorSOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a DBCO Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. DBCO is a strained alkyne commonly used in copper free click chemistry, specifically in the strain promoted azide alkyne cycloaddition (SPAAC) reaction. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further
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