Mal-Propionyl-PEG6-Val-Cit-PAB(m-PEG4)-Exatecan Size:10mg 933 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)NCCOCCOCCN=[N+]=[N-])CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC)

933 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)NCCOCCOCCN=[N+]=[N-])CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Hormone Receptor-Positive

Product Name Mal-Propionyl-Dap(m-PEG4)-Gly-Gly-Phe-Gly-PAB(m-PEG4)-Exatecan Synonyms CAS Number Related CAS Molecular Formula C77H95FN12O24 Molecular Weight 1591

which recruit the VHL or CRBN-ubiquitin E3 ligases to induce the degradation of CLIP-fusion proteins

Product Name Lenalidomide-PEG4-C2-azide Synonyms Lenalidomide-4'-PEG4-C2-azide CAS Number 2399455-55-9 Related CAS Molecular Formula C23H32N6O7 Molecular Weight 504

Mal-Propionyl-PEG6-Val-Cit-PAB(m-PEG4)-Exatecan Size:10mg 933 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)NCCOCCOCCN=[N+]=[N-])CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC)SOLU KNEX cleavable linker features a Val Cit dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG6 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I