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Sildenafil weight loss but only if you've eatenAbout Sildenafil ##accordion start## ##accordion item start## How does Sildenafil work? Sildenafil (the generic form of Viagra) works by inhibiting the enzyme PDE5. This increases the bodys level of cGMP (cyclic guanosine monophosphate), a chemical which relaxes the smooth muscle cells in the blood vessels within the penis. This means that more blood can flow into the penis during periods of sexual arousal, helping you to achieve and maintain a firmer