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Product Name DOTA-tris(t-Bu)ester-C5-propanamido-maleimide Synonyms CAS Number n/a Related CAS Molecular Formula C40H69N7O10 Molecular Weight 808
NRX-252262 acts as molecular glue in cells to promote the ubiquitylation and subsequent degradation of mutantbeta-catenin by the 26S proteasome
2341796-80-1 (2HCl salt) Molecular Formula C31H49Cl2N5O4S Molecular Weight 658
biotin-streptavidin binding or hydrophobic effects)
m-PEG8 is attached to the commonly used self-immolative para-aminobenzyl (PAB) moiety to further increase aqueous solubility
Mal-Propionyl-PEG4-Val-Cit-PAB(m-PEG8)-Exatecan Size:1mg Product Name DOTA-tris(t-Bu)ester-C5-propanamido-maleimide Synonyms CASSOLU KNEX cleavable linker features a Val Cit dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG4 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I
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