MC-Val-Cit-PAB(m-PEG8)-Exatecan cp 587 SMILES: CN(C)C1=CC=C2C(OC3=CC(C=CC3=C2C2=CC=C(C=C2C([O-])=O)C(=O)NCCN2C(=O)C=CC2=O)=[N+](C)C)=C1 Purity (HPLC):

587 SMILES: CN(C)C1=CC=C2C(OC3=CC(C=CC3=C2C2=CC=C(C=C2C([O-])=O)C(=O)NCCN2C(=O)C=CC2=O)=[N+](C)C)=C1 Purity (HPLC): ≥ 95% Shipping Conditions: room temperature Storage Conditions: Refrigerated Regulatory Statement: For Research Use Only

31 SMILES FC(F)(F)C1=CC(SC2=C(Cl)C=CC=C2Cl)=C(C(=O)N2CC3=CC=CC(C#N)=C3C2)C(=O)N1 Purity (HPLC) >= 95% Physical Appearance White solid Solubility DMSO

connected by a flexible polyethylene glycol (PEG) linker

Product Name 1-(methyl-d3)-2

BG-BCN is a SNAP-tag substrate containg BCN moiety for click chemistry applications

MC-Val-Cit-PAB(m-PEG8)-Exatecan cp 587 SMILES: CN(C)C1=CC=C2C(OC3=CC(C=CC3=C2C2=CC=C(C=C2C([O-])=O)C(=O)NCCN2C(=O)C=CC2=O)=[N+](C)C)=C1 Purity (HPLC):SOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures,