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Product Name DBCO-Dap(m-PEG4)-Val-Ala-PAB(m-PEG8)-Exatecan Synonyms CAS Number Related CAS Molecular Formula C90H115FN10O25 Molecular Weight 1755
DBCO has been widely used in click chemistry and reacts with azide without copper catalyst
Product Name DOTA-tris(t-Bu)ester-butyne Synonyms CAS Number 2125661-54-1 Related CAS Molecular Formula C32H57N5O7 Molecular Weight 623
Product Name Thalidomide-O-acetamido-PEG3-OH Synonyms Thalidomide-4'-O-acetamido-PEG3-OH CAS Number n/a Related CAS Molecular Formula C21H25N3O9 Molecular Weight 463
SHP099 suppresses RAS–ERK signalling to inhibit the proliferation of receptor-tyrosine-kinase-driven human cancer cells in vitro and is efficacious in mouse tumour xenograft models
Azide-Propionyl-Val-Cit-PAB(m-PEG8) ca Product Name DBCO-Dap(m-PEG4)-Val-Ala-PAB(m-PEG8)-Exatecan Synonyms CASSOLU KNEX cleavable linker features a Val Cit dipeptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing moietiessuch as PEG, amine containing groups, or polysarcosine (PSAR), to enhance aqueous solubility. Solubility and physicochemical properties can be finely tuned through selection
