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Molecular Glues for Targeted Protein Degradation: From Serendipity to Rational Discovery
445 SMILES OCCCCCCNC(=O)COC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only
TMR C2 maleimides have higher labeling efficiency
It forms a covalent bond with the CLIP-tag protein
Nat Chem Biol 2020
Propargyl-Acetyl-Val-Ala-PAB(m-PEG8)-MMAE Size:10mg Molecular Glues for Targeted ProteinSOLU KNEX cleavable linker features a Val Ala dipeptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly potent antimitotic agent that inhibits tubulin polymerization, leading to cell cycle arrest and subsequent apoptosis. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing
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