Mal-Propionyl-PEG6-Val-Ala-PAB(m-PEG4)-Exatecan Size:5mg 942 Purity (HPLC) >= 95%

942 Purity (HPLC) >= 95% Solubility DMSO

Datasheet         MSDS         COA

577 Purity (HPLC) >= 95% Solubility DMSO

Indisulam promotes the recruitment of RBM39 (RNA binding motif protein 39) to the CUL4-DCAF15 E3 ubiquitin ligase

Nitrogen Heterocycle Based Linker (NHBL)

Mal-Propionyl-PEG6-Val-Ala-PAB(m-PEG4)-Exatecan Size:5mg 942 Purity (HPLC) >= 95%SOLU KNEX cleavable linker features a Val Ala dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG6 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I