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Proteolysis targeting chimera (PROTAC) building block
Product Name DOTA-C4-alcohol Synonyms CAS Number n/a Related CAS Molecular Formula C20H37N5O8 Molecular Weight 475
NRX-2663 is an enhancer of the interaction between beta-catenin and beta-TrCP
404 SMILES CN1C(=O)C(C)=C2N(C(=O)N(C3CC3)C(=O)C2=C1NC1=C(F)C=C(I)C=C1)C1=CC(NC(C)=O)=CC=C1 Purity (HPLC) >= 95% Physical Appearance White solid Solubility DMSO
Indisulam promotes the recruitment of RBM39 (RNA binding motif protein 39) to the CUL4-DCAF15 E3 ubiquitin ligase
Mal-Lys(m-PEG4)-Val-Cit-PAB(m-PEG4)-Exatecan Size:25mg Proteolysis targeting chimera (PROTAC) buildingSOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Mal Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. Additionally, m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by
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