Propargyl-Gly(m-PEG4)-Val-Ala-PAB(m-PEG8)-PNP PEG4 BI-3802 has antitumor activity

BI-3802 has antitumor activity

Product Name Mal-Lys(m-PEG4)-Gly-Gly-Phe-Gly-PAB-PNP Synonyms CAS Number Related CAS Molecular Formula C49H60N8O17 Molecular Weight 1033

S)-AHPC-CO-PEG3-Br Synonyms CAS Number n/a Related CAS Molecular Formula C31H45BrN4O7S Molecular Weight 697

Product Name DOTA-tris(t-Bu)ester-C5-amine Synonyms CAS Number n/a Related CAS Molecular Formula C33H64N6O7 Molecular Weight 656

Rational discovery of molecular glue degraders via scalable chemical profiling

Propargyl-Gly(m-PEG4)-Val-Ala-PAB(m-PEG8)-PNP PEG4 BI-3802 has antitumor activitySOLU KNEX cleavable linker features a Val Ala dipeptide. In this product, a Propargyl Gly(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The propargyl functional group is widely employed in click chemistry to undergo selective cycloaddition with azides. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The PNP