Mal-Lys(m-PEG4)-Val-Ala-PAB(m-PEG8) azide ACS Chemical Biology 2020

ACS Chemical Biology 2020

1038/s41586-020-2760-4

Product Name Thalidomide-O-PEG3-C2-azide Synonyms Thalidomide-4'-O-PEG3-C2-azide CAS Number 2758432-01-6 Related CAS Molecular Formula C21H25N5O8 Molecular Weight 475

NCCCNC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name DBCO-Dap(m-PEG4)-Val-Cit-PAB-PNP Synonyms CAS Number Related CAS Molecular Formula C57H70N10O15 Molecular Weight 1135

Mal-Lys(m-PEG4)-Val-Ala-PAB(m-PEG8) azide ACS Chemical Biology 2020SOLU KNEX cleavable linker features a Val Ala dipeptide. In this product, a Mal Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing moietiessuch as PEG, amine