Mal-Propionyl-PEG8-Gly-Gly-Phe-Gly-PAB(m-PEG4)-MMAE Size:1mg S)-AHPC-CO-PEG3-propargyl Synonyms CAS Number 2374122-30-0

S)-AHPC-CO-PEG3-propargyl Synonyms CAS Number 2374122-30-0 Related CAS Molecular Formula C32H44N4O7S Molecular Weight 628

Ready for conjugation to a target protein ligand to form PROTACs containing Lenalidomide as cereblon ligand

Journal of Medicinal Chemistry

TMX-4100 can be used for the research of multiple myeloma

Product Name Azide-Dap(m-PEG4)-Val-Ala-PAB(m-PEG8)-MMAE Synonyms CAS Number Related CAS Molecular Formula C86H145N13O26 Molecular Weight 1777

Mal-Propionyl-PEG8-Gly-Gly-Phe-Gly-PAB(m-PEG4)-MMAE Size:1mg S)-AHPC-CO-PEG3-propargyl Synonyms CAS Number 2374122-30-0SOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG8 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a