Mal-Propionyl-PEG6-Gly-Gly-Phe-Gly-PAB(m-PEG4)-PNP Size:50mg 26 SMILES CC1(N)CCN(CC1)C1=CN=C(C(N)=N1)C1=C(Cl)C(Cl)=CC=C1 Purity (HPLC)

26 SMILES CC1(N)CCN(CC1)C1=CN=C(C(N)=N1)C1=C(Cl)C(Cl)=CC=C1 Purity (HPLC) >= 95% Physical Appearance White solid Solubility DMSO

4-diethylamine CAS Number 6531-38-0 Related CAS Molecular Formula C8H20N4 Molecular Weight 172

DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance

NCCCCCNC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Fmoc-Val-Cit-PAB-PNP is a cleavable ADC linker used in antibody–drug conjugate (ADC) development

Mal-Propionyl-PEG6-Gly-Gly-Phe-Gly-PAB(m-PEG4)-PNP Size:50mg 26 SMILES CC1(N)CCN(CC1)C1=CN=C(C(N)=N1)C1=C(Cl)C(Cl)=CC=C1 Purity (HPLC)SOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG6 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The PNP (para nitrophenyl) moiety serves as an