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Molecular Glues for Targeted Protein Degradation: From Serendipity to Rational Discovery
S)-AHPC-CO-C4-alkyne Synonyms CAS Number 2374122-28-6 Related CAS Molecular Formula C29H38N4O4S Molecular Weight 538
415 Purity (HPLC) >= 95% Solubility DMSO
no extreme temperatures or solvents are required
544 Purity (HPLC) >= 95% Solubility DMSO
Mal-Propionyl-PEG2-Gly-Gly-Phe-Gly-PAB(m-PEG8)-MMAE Size:10mg Molecular Glues for Targeted ProteinSOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG2 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a
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