Mal-Lys(m-PEG4)-Gly-Gly-Phe-Gly-PAB(m-PEG8)-Exatecan aniline 69 SMILES CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCOCCOCCBr)C(C)(C)C)C=C1 Purity (HPLC)

69 SMILES CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCOCCOCCBr)C(C)(C)C)C=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

1038/35104500

276 SMILES NCCN1CCN(CCN)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name CA-amide-PEG3-Biotin Synonyms biotin Halotag Ligand PEG3 CAS Number N/A Related CAS N/A Molecular Formula C29H53ClN4O8S Molecular Weight 653

and radiotherapeutic agents

Mal-Lys(m-PEG4)-Gly-Gly-Phe-Gly-PAB(m-PEG8)-Exatecan aniline 69 SMILES CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCOCCOCCBr)C(C)(C)C)C=C1 Purity (HPLC)SOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. In this product, a Mal Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage