Mal-Acetyl-Dap(m-PEG4)-Val-Ala-PAB(m-PEG8)-Exatecan Biotin Product Name Mal-Propionyl-PEG6-Val-Cit-PAB(m-PEG4)-Exatecan Synonyms CAS

Product Name Mal-Propionyl-PEG6-Val-Cit-PAB(m-PEG4)-Exatecan Synonyms CAS Number Related CAS Molecular Formula C75H102FN11O24 Molecular Weight 1560

454 SMILES OC(=O)CCOCCOCCOCCOC1=CC=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name DOTA-PEG6-C2-azide Synonyms CAS Number n/a Related CAS Molecular Formula C30H56N8O13 Molecular Weight 736

263 SMILES BrCCOCCCC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name Lenalidomide-acetamido-O-PEG1-OH Synonyms Lenalidomide-4'-acetamido-O-PEG1-OH CAS Number n/a Related CAS Molecular Formula C17H19N3O6 Molecular Weight 361

Mal-Acetyl-Dap(m-PEG4)-Val-Ala-PAB(m-PEG8)-Exatecan Biotin Product Name Mal-Propionyl-PEG6-Val-Cit-PAB(m-PEG4)-Exatecan Synonyms CASSOLU KNEX cleavable linker features a Val Ala dipeptide. In this product, a Mal Acetyl Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The Mal Acetyl group may also improve retro Michael addition stability during antibody conjugation. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The payload is Exatecan,