Mal-Propionyl-PEG8-Val-Ala-PAB(m-PEG4)-Exatecan probe 43 SMILES: OC1=CC2=C(C=C1)C1(OC(=O)C3=CC(=CC=C13)C(=O)NCCCN=[N]#N)C1=CC=C(O)C=C1O2 Purity (HPLC):

43 SMILES: OC1=CC2=C(C=C1)C1(OC(=O)C3=CC(=CC=C13)C(=O)NCCCN=[N]#N)C1=CC=C(O)C=C1O2 Purity (HPLC): ≥ 95% Shipping Conditions: room temperature Storage Conditions: Refrigerated Regulatory Statement: For Research Use Only

314 SMILES O=C1N(CC2=C(NCC#C)C=CC=C12)C1CCC(=O)NC1=O Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name BI-3802 Synonyms CAS Number 2166387-65-9 Related CAS Molecular Formula C25H31ClN6O3 Molecular Weight 499

Product Name Mal-Acetyl-Dap(m-PEG4)-Gly-Gly-Phe-Gly-PAB(m-PEG8)-Exatecan Synonyms CAS Number Related CAS Molecular Formula C84H109FN12O28 Molecular Weight 1753

Biotin-labeled biomolecules can be bound to avidin or streptavidin for further purification and detection

Mal-Propionyl-PEG8-Val-Ala-PAB(m-PEG4)-Exatecan probe 43 SMILES: OC1=CC2=C(C=C1)C1(OC(=O)C3=CC(=CC=C13)C(=O)NCCCN=[N]#N)C1=CC=C(O)C=C1O2 Purity (HPLC):SOLU KNEX cleavable linker features a Val Ala dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG8 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I