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The strain in DBCO’s cyclooctyne ring drives the reaction forward by releasing energy when it transitions to the triazole product
A general strategy to develop cell permeable and fluorogenic probes for multicolour nanoscopy
Product Name Fmoc-Gly-Gly-Phe-Gly-PAB(m-PEG8) Synonyms CAS Number Related CAS Molecular Formula C55H72N6O16 Molecular Weight 1073
NCCCCNC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only
585 Purity (HPLC) >= 95% Solubility DMSO
DBCO-Lys(m-PEG4)-Gly-Gly-Phe-Gly-PAB(m-PEG4)-Exatecan Size:25mg The strain in DBCO’s cyclooctyneSOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. In this product, a DBCO Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. DBCO is a strained alkyne commonly used in copper free click chemistry, specifically in the strain promoted azide alkyne cycloaddition (SPAAC) reaction. Additionally, m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to
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