CRBN5-SNAP2-0C-PIP Size:100nmol 32 SMILES COCC(=O)N[C@@H](CC1=CC=C(C=C1)C1=CC(Cl)=CC(Cl)=C1)[C@H](O)[C@@H](O)C(C)=O Purity (HPLC)

32 SMILES COCC(=O)N[C@@H](CC1=CC=C(C=C1)C1=CC(Cl)=CC(Cl)=C1)[C@H](O)[C@@H](O)C(C)=O Purity (HPLC) >= 95% Physical Appearance White solid Solubility DMSO

SOLU-KNEX® cleavable linker features a Val-Cit dipeptide

Trametinib binds KRS-MEK and disrupts RAF-MEK

Product Name: 6-ROX alkyne Synonyms: 6-Carboxy-X-rhodamine alkyne CAS Number: N/A Molecular Formula: C36H33N3O4 Molecular Weight: 571

707 SMILES OC(=O)CN1CCN(CC(O)=O)CCN(CC(=O)NCCCCCNC(=O)CCN2C(=O)C=CC2=O)CCN(CC(O)=O)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

CRBN5-SNAP2-0C-PIP Size:100nmol 32 SMILES COCC(=O)N[C@@H](CC1=CC=C(C=C1)C1=CC(Cl)=CC(Cl)=C1)[C@H](O)[C@@H](O)C(C)=O Purity (HPLC)CRBN5 SNAP2 0C PIP is a SNAP PROteolysis TArgeting Chimera (SNAP PROTAC), which recruit the VHL or CRBN ubiquitin E3 ligases to induce the degradation of SNAP fusion proteins. Endogenous tagging enabled the visualization and the selective depletion of a SNAP clathrin light chain fusion protein using SNAP PROTACs. The addition of PROTACs to the SNAP tag reagent toolbox facilitates the comprehensive analysis of protein function with a single gene