Mal-Propionyl-PEG2-Val-Cit-PAB(m-PEG8) Size:100mg Development of PDE6D and CK1a

Development of PDE6D and CK1a Degraders through Chemical Derivatization of FPFT-2216

003 Purity (HPLC) >= 95% Solubility DMSO

Product Name Mal-Propionyl-PEG8-Val-Cit-PAB(m-PEG4)-MMAE Synonyms CAS Number Related CAS Molecular Formula C93H155N13O31 Molecular Weight 1951

33 Purity (HPLC) >= 95% Solubility DMSO

5 SMILES [H][C@]12CS[C@@H](CCCCC(=O)NCCOCCOCCN=[N+]=[N-])[C@@]1([H])NC(=O)N2 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Mal-Propionyl-PEG2-Val-Cit-PAB(m-PEG8) Size:100mg Development of PDE6D and CK1aSOLU KNEX cleavable linker features a Val Cit dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG2 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. Derived from established ADC linker architectures, SOLU KNEX