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Spider-Man will be Standard legal, so something like Anti-Venom, Horrifying Healer can really shake up the format's metagame

So that means triggering your Hedron Crab also triggers this homarid mercenary, as would targeting them with something like Glimpse the Unthinkable

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If your opponent has to kill your Esper Sentinel with something like Declaration in Stone or Lightning Strike for two mana, you are already winning the exchange, with your opponent having to trade down mana-wise

If you do, put a +1/+1 counter on Isu the Abominable

Im only including this here because its sometimes relevant in Eternal formats besides Commander