Tanshinone IIA sulfonate (sodium) Double Scale ~10-fold more selective for VEGFR2/3

~10-fold more selective for VEGFR2/3 against FGFR1

CYP1A2 and CYP1B1 with IC50 of 6

2-Methoxyestradiol (2-MeOE2) depolymerizes microtubules and blocks HIF-1

12/Case - COP

Lopinavir is a potent HIV protease inhibitor with Ki of 1

Tanshinone IIA sulfonate (sodium) Double Scale ~10-fold more selective for VEGFR2/3Sodium tanshinone IIA sulfonate (STS) is a water soluble derivative of tanshinone IIA isolated as the main pharmacologically active natural compound from a traditional Chinese herbal medicine, the dried root of Salvia miltiorrhiza Bunge known as Danshen; a potent negative allosteric modulator of the human purinergic receptor P2X7.